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ea0029p1355 | Pituitary Basic | ICEECE2012

Lycopene and β-carotene induce growth-inhibitory and proapoptotic effects on pituitary tumor cells: the mechanism could involve Connexin 43

Haddad N. , Teodoro A. , Soares N. , Oliveira F. , Mattos R. , Gomes F. , Gadelha M. , Nasciutti L. , Miranda-Alves L.

Pituitary adenomas account for ~1015% of intracranial tumors and result in morbidity due to both altered hormonal patterns as well as side effects of therapy. Currently, great attention has been given to natural coumpouds from functional foods. Among these substances, we highlight that the consumption of carotenoids is associated with reduced risk of chronic diseases including cancer and vascular diseases. In this study we evaluate the influence of β-carotene and ly...

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ea0041ep914 | Pituitary - Clinical | ECE2016

The association between adenoma size classification and the hormone hypersecretion in acromegaly

Soares Luana F , Outuki Giovana , Ludwig Natasha G , Miksza Daniele R , Fiorenzano Gracielle R , Mattos Alexandro Marcio S , Carrilho Alexandre J F , Mazzuco Tania L

Introduction: Acromegaly is a chronic disease caused by growth hormone (GH) oversecretion. A pituitary macroadenoma is found in mostly of cases, but the secretion pattern of GH and insulin-like growth factor 1 (IGF-1) and the natural history of somatotropinomas are heterogeneous. The objective of the present study was to evaluate the relationship between tumor size, GH and IGF-1 levels in patients diagnosed with acromegaly.Methods: A cross-sectional, obs...

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Endocrine Abstracts

Lycopene and β-carotene induce growth-inhibitory and proapoptotic effects on pituitary tumor cells: the mechanism could involve Connexin 43

The association between adenoma size classification and the hormone hypersecretion in acromegaly

BiosciAbstracts